How we enable our vision
We are focused on bringing cancer immunotherapy into the next generation. We believe that we can accomplish this by applying the following principles:
- Exploiting the full potential of the immune system.
Our broad pipeline includes mRNA-based immune activators, antigen-targeting T cells and antibodies, and defined immunomodulators of various immune cell mechanisms. This portfolio is designed to mirror the evolution of the immune system to rely on multiple complementary pathways.
- Broadening the universe of patients benefiting from cancer immunotherapy.
We discover and exploit novel targets and target combinations. Our aim is to extend the utility of immunotherapy to patient populations that are not currently amenable or do not benefit from the targets of current immunotherapies. One example are patients with low mutational load tumors, such as pancreatic and prostate cancer, which we address with tumor-associated antigens.
- Improving the success rate.
We engineer and develop highly potent drug candidates designed to avoid compromising precision for the specific target. We further augment activity and counteract resistance mechanisms by combining compounds with non-overlapping, synergistic mechanisms of action, such as combining our FixVac immunotherapy with our novel CAR T therapies.
- Focusing on curative approaches.
The root cause of recurrence or lack of tumor eradication is interindividual variability and cancer heterogeneity. Addressing this biological reality is one of the mandatory design aspects of the product candidates we develop. For example, each of our cancer immunotherapies incorporates multiple targets in order to account for this variability.
We have applied these four guiding principles to a broad suite of therapeutic platforms optimized for a distinct mode of action, high precision targeting, high potency and efficacy. We expect each platform to yield a pipeline of drug candidates for further development.
We focus on the patient to provide unique treatments
We believe that harnessing complementary, potentially synergistic modes of action increases the likelihood of therapeutic success, reduces the risk of emergence of secondary resistance mechanisms, and also unlocks a larger potential market. Critically, this approach allows us to pursue a technology agnostic approach, providing the most appropriate therapeutic platform or a combination thereof for the intended patient and purpose.
FROM PATIENT TO PATIENT-SPECIFIC CANCER TREATMENT
Our computational approach to individualized immunotherapy
Bioinformatics are critical in the production of individualized therapies. We have accumulated a high level of experience in bioinformatics of mutation detection, cancer genomics and immunotherapy through our ongoing research and preclinical studies and clinical trials. Our validated patient-centric bioinformatic process, as illustrated below, allows the application of complex algorithms to the patient’s data in the context of drug manufacturing. Our bioinformatics processes are robust and scalable, incorporating our experience handling genomic data in a high throughput environment, as we target making on-demand production of individualized immunotherapies commercially viable.
OUR VALIDATED PATIENT-CENTRIC BIOINFORMATIC PROCESS
Our platforms leverage the following four drug classes:
We believe that the breadth of our technology is greater than the sum of its parts as it positions us to combine modes of action in a coordinated way to treat cancer in a more efficacious manner than current existing therapies. Our synergistic platform and manufacturing capabilities place us at the forefront of the paradigm shift towards individualized immunotherapies.
- Our off-the-shelf shared antigen immunotherapy, or FixVac
- Our individualized neoantigen specific immunotherapy, or iNeST, in collaboration with Genentech
- Our intratumoral immunotherapy, in collaboration with Sanofi
- Our two platforms in which we use mRNA to express directly in the patient either (a) particular antibodies, or RiboMabs, or (b) specific cytokines, or RiboCytokines
In collaboration with Pfizer and Genevant, we are also leveraging our mRNA technology beyond oncology to treat influenza and rare diseases.