Pipeline

EXPLORE OUR PRODUCT CANDIDATES
Biontech-Pipeline_V2020.pdf
DRUGCLASS
PLATFORM
PHASE
PARTNERS
SEARCH
mRNA
FixVac
BNT111
BNT111
PHASE
PRE123
Indication:
Advanced Melanoma (Adjuvant and Metastatic)
Rights/Collaborations:
Global
PHASE
PRE123
Indication:
Advanced Melanoma (Adjuvant and Metastatic)
Rights/Collaborations:
Global

BNT111 is developed for the treatment of advanced melanoma in patients with metastatic tumors and as an adjuvant treatment after tumor resection. It is designed to elicit an immune response to…

BNT111 is developed for the treatment of advanced melanoma in patients with metastatic tumors and as an adjuvant treatment after tumor resection. It is designed to elicit an immune response to four melanoma-associated antigens.

We are currently studying BNT111 in an ongoing Phase 1 clinical trial. Find out more about the Lipo-MERIT study here.

An earlier version of the BNT111 only targeting NY-ESO-1 and tyrosinase has already completed a first-in-human dose escalation study (MERIT study) evaluating the safety and tolerability of intranodal administration in patients with advanced melanoma. See more information on the clinical study here.

DRUG CLASS

mRNA Therapeutics (mRNA)

We are utilizing messenger ribonucleic acid, or mRNA, to deliver genetic information to cells, where it is used to express proteins for therapeutic effect. We are developing a portfolio of immunotherapies that utilize four different mRNA formats and three different formulations to derive five distinct platforms for the treatment of cancer. Three of these platforms are currently in human testing:

  1. our off-the-shelf shared antigen immunotherapy, or FixVac
  2. our individualized neoantigen specific immunotherapy, or iNeST, in collaboration with Genentech
  3. our intratumoral immunotherapy, in collaboration with Sanofi.

In addition, we are developing two platforms in which we use mRNA to express directly in the patient either (a) particular antibodies, or RiboMabs, or (b) specific cytokines, or RiboCytokines. In collaboration with Pfizer and Genevant, we are also leveraging our mRNA technology beyond oncology to treat influenza and rare diseases.

More about mRNA

PLATFORM

Fixed combination of shared cancer antigens (FixVac)

Fixed combination of shared cancer antigens

  • Concept: Cancer immunotherapies targeting shared antigens that we have identified to be frequently expressed across patients with a specific cancer type.
  • mRNA Format: Optimized mRNA providing superior immunogenicity.
  • mRNA Delivery Formulation: Proprietary size- and charge-based RNA-LPX targeting DCs.
  • Development Approach: Worldwide rights; wholly owned.
  • Lead Candidate: BNT111 for metastatic melanoma.
  • Data Highlights: Four partial responses and eight stable diseases in 22 patients with metastatic lesions at enrollment, following BNT111 monotherapy.

More about FixVac

mRNA
FixVac
BNT112
BNT112
PHASE
PRE123
Indication:
Prostate Cancer
Rights/Collaborations:
Global
PHASE
PRE123
Indication:
Prostate Cancer
Rights/Collaborations:
Global

We are currently studying BNT112 in an open-label, multi-center, first-in-human Phase 1/2 individual dose titration study in patients with metastatic Castration Resistant Prostate Cancer (mCRPC)…

We are currently studying BNT112 in an open-label, multi-center, first-in-human Phase 1/2 individual dose titration study in patients with metastatic Castration Resistant Prostate Cancer (mCRPC) and high-risk localized prostate cancer, or LPC.

DRUG CLASS

mRNA Therapeutics (mRNA)

We are utilizing messenger ribonucleic acid, or mRNA, to deliver genetic information to cells, where it is used to express proteins for therapeutic effect. We are developing a portfolio of immunotherapies that utilize four different mRNA formats and three different formulations to derive five distinct platforms for the treatment of cancer. Three of these platforms are currently in human testing:

  1. our off-the-shelf shared antigen immunotherapy, or FixVac
  2. our individualized neoantigen specific immunotherapy, or iNeST, in collaboration with Genentech
  3. our intratumoral immunotherapy, in collaboration with Sanofi.

In addition, we are developing two platforms in which we use mRNA to express directly in the patient either (a) particular antibodies, or RiboMabs, or (b) specific cytokines, or RiboCytokines. In collaboration with Pfizer and Genevant, we are also leveraging our mRNA technology beyond oncology to treat influenza and rare diseases.

More about mRNA

PLATFORM

Fixed combination of shared cancer antigens (FixVac)

Fixed combination of shared cancer antigens

  • Concept: Cancer immunotherapies targeting shared antigens that we have identified to be frequently expressed across patients with a specific cancer type.
  • mRNA Format: Optimized mRNA providing superior immunogenicity.
  • mRNA Delivery Formulation: Proprietary size- and charge-based RNA-LPX targeting DCs.
  • Development Approach: Worldwide rights; wholly owned.
  • Lead Candidate: BNT111 for metastatic melanoma.
  • Data Highlights: Four partial responses and eight stable diseases in 22 patients with metastatic lesions at enrollment, following BNT111 monotherapy.

More about FixVac

mRNA
FixVac
BNT113
BNT113
PHASE
PRE123
Indication:
HPV16+ Head and Neck Cancer
Rights/Collaborations:
Global
PHASE
PRE123
Indication:
HPV16+ Head and Neck Cancer
Rights/Collaborations:
Global

BNT113 is designed to elicit an immune response against the well-characterized HPV16-derived oncoproteins E6 and E7, which are strongly immunogenic, viral neoantigens that are found in HPV16-…

BNT113 is designed to elicit an immune response against the well-characterized HPV16-derived oncoproteins E6 and E7, which are strongly immunogenic, viral neoantigens that are found in HPV16-positive solid cancers such as head and neck squamous cell carcinoma. BNT113 is under development for the treatment of HPV-positive head and neck cancer and is currently being studied by the University of Southampton in an ongoing investigator-sponsored Phase 1/2 basket study in HPV-positive cancers, including head and neck cancer. Find out more on the study here.

DRUG CLASS

mRNA Therapeutics (mRNA)

We are utilizing messenger ribonucleic acid, or mRNA, to deliver genetic information to cells, where it is used to express proteins for therapeutic effect. We are developing a portfolio of immunotherapies that utilize four different mRNA formats and three different formulations to derive five distinct platforms for the treatment of cancer. Three of these platforms are currently in human testing:

  1. our off-the-shelf shared antigen immunotherapy, or FixVac
  2. our individualized neoantigen specific immunotherapy, or iNeST, in collaboration with Genentech
  3. our intratumoral immunotherapy, in collaboration with Sanofi.

In addition, we are developing two platforms in which we use mRNA to express directly in the patient either (a) particular antibodies, or RiboMabs, or (b) specific cytokines, or RiboCytokines. In collaboration with Pfizer and Genevant, we are also leveraging our mRNA technology beyond oncology to treat influenza and rare diseases.

More about mRNA

PLATFORM

Fixed combination of shared cancer antigens (FixVac)

Fixed combination of shared cancer antigens

  • Concept: Cancer immunotherapies targeting shared antigens that we have identified to be frequently expressed across patients with a specific cancer type.
  • mRNA Format: Optimized mRNA providing superior immunogenicity.
  • mRNA Delivery Formulation: Proprietary size- and charge-based RNA-LPX targeting DCs.
  • Development Approach: Worldwide rights; wholly owned.
  • Lead Candidate: BNT111 for metastatic melanoma.
  • Data Highlights: Four partial responses and eight stable diseases in 22 patients with metastatic lesions at enrollment, following BNT111 monotherapy.

More about FixVac

mRNA
FixVac
BNT114
BNT114
PHASE
PRE123
Indication:
Triple Negative Breast Cancer
Rights/Collaborations:
Global
PHASE
PRE123
Indication:
Triple Negative Breast Cancer
Rights/Collaborations:
Global

BNT114 is designed to elicit an immune response to selected antigens that are found in breast cancers. We are evaluating BNT114 for the treatment of triple negative breast cancer in an ongoing…

BNT114 is designed to elicit an immune response to selected antigens that are found in breast cancers. We are evaluating BNT114 for the treatment of triple negative breast cancer in an ongoing three-arm clinical trial as both a monotherapy and in combination with our BNT122 individualized iNeST immunotherapy. Find out more about the ongoing study here.

DRUG CLASS

mRNA Therapeutics (mRNA)

We are utilizing messenger ribonucleic acid, or mRNA, to deliver genetic information to cells, where it is used to express proteins for therapeutic effect. We are developing a portfolio of immunotherapies that utilize four different mRNA formats and three different formulations to derive five distinct platforms for the treatment of cancer. Three of these platforms are currently in human testing:

  1. our off-the-shelf shared antigen immunotherapy, or FixVac
  2. our individualized neoantigen specific immunotherapy, or iNeST, in collaboration with Genentech
  3. our intratumoral immunotherapy, in collaboration with Sanofi.

In addition, we are developing two platforms in which we use mRNA to express directly in the patient either (a) particular antibodies, or RiboMabs, or (b) specific cytokines, or RiboCytokines. In collaboration with Pfizer and Genevant, we are also leveraging our mRNA technology beyond oncology to treat influenza and rare diseases.

More about mRNA

PLATFORM

Fixed combination of shared cancer antigens (FixVac)

Fixed combination of shared cancer antigens

  • Concept: Cancer immunotherapies targeting shared antigens that we have identified to be frequently expressed across patients with a specific cancer type.
  • mRNA Format: Optimized mRNA providing superior immunogenicity.
  • mRNA Delivery Formulation: Proprietary size- and charge-based RNA-LPX targeting DCs.
  • Development Approach: Worldwide rights; wholly owned.
  • Lead Candidate: BNT111 for metastatic melanoma.
  • Data Highlights: Four partial responses and eight stable diseases in 22 patients with metastatic lesions at enrollment, following BNT111 monotherapy.

More about FixVac

mRNA
FixVac
BNT115
BNT115
PHASE
PRE123
Indication:
Ovarian Cancer
Rights/Collaborations:
Global
PHASE
PRE123
Indication:
Ovarian Cancer
Rights/Collaborations:
Global

We are currently studying BNT115 in a Phase 1 trial for the treatment of ovarian cancer.

We are currently studying BNT115 in a Phase 1 trial for the treatment of ovarian cancer.

DRUG CLASS

mRNA Therapeutics (mRNA)

We are utilizing messenger ribonucleic acid, or mRNA, to deliver genetic information to cells, where it is used to express proteins for therapeutic effect. We are developing a portfolio of immunotherapies that utilize four different mRNA formats and three different formulations to derive five distinct platforms for the treatment of cancer. Three of these platforms are currently in human testing:

  1. our off-the-shelf shared antigen immunotherapy, or FixVac
  2. our individualized neoantigen specific immunotherapy, or iNeST, in collaboration with Genentech
  3. our intratumoral immunotherapy, in collaboration with Sanofi.

In addition, we are developing two platforms in which we use mRNA to express directly in the patient either (a) particular antibodies, or RiboMabs, or (b) specific cytokines, or RiboCytokines. In collaboration with Pfizer and Genevant, we are also leveraging our mRNA technology beyond oncology to treat influenza and rare diseases.

More about mRNA

PLATFORM

Fixed combination of shared cancer antigens (FixVac)

Fixed combination of shared cancer antigens

  • Concept: Cancer immunotherapies targeting shared antigens that we have identified to be frequently expressed across patients with a specific cancer type.
  • mRNA Format: Optimized mRNA providing superior immunogenicity.
  • mRNA Delivery Formulation: Proprietary size- and charge-based RNA-LPX targeting DCs.
  • Development Approach: Worldwide rights; wholly owned.
  • Lead Candidate: BNT111 for metastatic melanoma.
  • Data Highlights: Four partial responses and eight stable diseases in 22 patients with metastatic lesions at enrollment, following BNT111 monotherapy.

More about FixVac

mRNA
FixVac
BNT116
BNT116
PHASE
PRE123
Indication:
NSCLC
Rights/Collaborations:
Global
PHASE
PRE123
Indication:
NSCLC
Rights/Collaborations:
Global

We are also exploring FixVac development candidates in NSCLC.

We are also exploring FixVac development candidates in NSCLC.

DRUG CLASS

mRNA Therapeutics (mRNA)

We are utilizing messenger ribonucleic acid, or mRNA, to deliver genetic information to cells, where it is used to express proteins for therapeutic effect. We are developing a portfolio of immunotherapies that utilize four different mRNA formats and three different formulations to derive five distinct platforms for the treatment of cancer. Three of these platforms are currently in human testing:

  1. our off-the-shelf shared antigen immunotherapy, or FixVac
  2. our individualized neoantigen specific immunotherapy, or iNeST, in collaboration with Genentech
  3. our intratumoral immunotherapy, in collaboration with Sanofi.

In addition, we are developing two platforms in which we use mRNA to express directly in the patient either (a) particular antibodies, or RiboMabs, or (b) specific cytokines, or RiboCytokines. In collaboration with Pfizer and Genevant, we are also leveraging our mRNA technology beyond oncology to treat influenza and rare diseases.

More about mRNA

PLATFORM

Fixed combination of shared cancer antigens (FixVac)

Fixed combination of shared cancer antigens

  • Concept: Cancer immunotherapies targeting shared antigens that we have identified to be frequently expressed across patients with a specific cancer type.
  • mRNA Format: Optimized mRNA providing superior immunogenicity.
  • mRNA Delivery Formulation: Proprietary size- and charge-based RNA-LPX targeting DCs.
  • Development Approach: Worldwide rights; wholly owned.
  • Lead Candidate: BNT111 for metastatic melanoma.
  • Data Highlights: Four partial responses and eight stable diseases in 22 patients with metastatic lesions at enrollment, following BNT111 monotherapy.

More about FixVac

mRNA
iNeST
BNT122
BNT122
PHASE
PRE123
Indication:
1L Melanoma with CPI
Rights/Collaborations:
Genentech
PHASE
PRE123
Indication:
1L Melanoma with CPI
Rights/Collaborations:
Genentech

We and our collaborator Genentech are developing RO7198457 (BNT122) for the treatment of metastatic melanoma and other solid tumors. We are currently conducting a randomized Phase 2 trial in…

We and our collaborator Genentech are developing RO7198457 (BNT122) for the treatment of metastatic melanoma and other solid tumors. We are currently conducting a randomized Phase 2 trial in collaboration with Genentech in first-line melanoma in combination with pembrolizumab. Find out more about the study here.

DRUG CLASS

mRNA Therapeutics (mRNA)

We are utilizing messenger ribonucleic acid, or mRNA, to deliver genetic information to cells, where it is used to express proteins for therapeutic effect. We are developing a portfolio of immunotherapies that utilize four different mRNA formats and three different formulations to derive five distinct platforms for the treatment of cancer. Three of these platforms are currently in human testing:

  1. our off-the-shelf shared antigen immunotherapy, or FixVac
  2. our individualized neoantigen specific immunotherapy, or iNeST, in collaboration with Genentech
  3. our intratumoral immunotherapy, in collaboration with Sanofi.

In addition, we are developing two platforms in which we use mRNA to express directly in the patient either (a) particular antibodies, or RiboMabs, or (b) specific cytokines, or RiboCytokines. In collaboration with Pfizer and Genevant, we are also leveraging our mRNA technology beyond oncology to treat influenza and rare diseases.

More about mRNA

PLATFORM

Individualized Neoantigen Specific Immunotherapy (iNeST)

Individualized Neoantigen Specific Immunotherapy

  • Concept: Individualized cancer immunotherapy targeting neoantigens identified on a patient by patient basis and selected for immunogenicity.
  • mRNA Format: Optimized mRNA providing superior immunogenicity.
  • mRNA Delivery Formulation: Proprietary size- and charge-based RNA-LPX targeting DCs.
  • Development Approach: 50:50 cost share with Genentech.
  • Lead Indication: RO7198457 (BNT122) as a first-line melanoma therapy in combination with pembrolizumab.
  • Data Highlights: In a previous Phase 1 trial of BNT121, we observed first-in-human data in 13 patients with metastatic melanoma demonstrating stable progression-free survival in nine patients for up to 41 months, and additional objective responses in three of five patients with metastatic disease at time of treatment with iNeST including one patient receiving combination therapy. We also observed a significant decrease in the cumulative recurrence rate post-treatment as compared to pre-treatment.

More about iNeST

mRNA
iNeST
BNT122
BNT122
PHASE
PRE123
Indication:
Locally advanced or metastatic solid tumors
Rights/Collaborations:
Genentech
PHASE
PRE123
Indication:
Locally advanced or metastatic solid tumors
Rights/Collaborations:
Genentech

We are also studying RO7198457 (BNT122) as a monotherapy and in combination with atezolizumab in a Phase 1a/1b basket study of patients with locally advanced or metastatic solid tumors (including…

We are also studying RO7198457 (BNT122) as a monotherapy and in combination with atezolizumab in a Phase 1a/1b basket study of patients with locally advanced or metastatic solid tumors (including in melanoma, non-small cell lung cancer, bladder cancer as well as other solid tumors). Find out more about the study here.

DRUG CLASS

mRNA Therapeutics (mRNA)

We are utilizing messenger ribonucleic acid, or mRNA, to deliver genetic information to cells, where it is used to express proteins for therapeutic effect. We are developing a portfolio of immunotherapies that utilize four different mRNA formats and three different formulations to derive five distinct platforms for the treatment of cancer. Three of these platforms are currently in human testing:

  1. our off-the-shelf shared antigen immunotherapy, or FixVac
  2. our individualized neoantigen specific immunotherapy, or iNeST, in collaboration with Genentech
  3. our intratumoral immunotherapy, in collaboration with Sanofi.

In addition, we are developing two platforms in which we use mRNA to express directly in the patient either (a) particular antibodies, or RiboMabs, or (b) specific cytokines, or RiboCytokines. In collaboration with Pfizer and Genevant, we are also leveraging our mRNA technology beyond oncology to treat influenza and rare diseases.

More about mRNA

PLATFORM

Individualized Neoantigen Specific Immunotherapy (iNeST)

Individualized Neoantigen Specific Immunotherapy

  • Concept: Individualized cancer immunotherapy targeting neoantigens identified on a patient by patient basis and selected for immunogenicity.
  • mRNA Format: Optimized mRNA providing superior immunogenicity.
  • mRNA Delivery Formulation: Proprietary size- and charge-based RNA-LPX targeting DCs.
  • Development Approach: 50:50 cost share with Genentech.
  • Lead Indication: RO7198457 (BNT122) as a first-line melanoma therapy in combination with pembrolizumab.
  • Data Highlights: In a previous Phase 1 trial of BNT121, we observed first-in-human data in 13 patients with metastatic melanoma demonstrating stable progression-free survival in nine patients for up to 41 months, and additional objective responses in three of five patients with metastatic disease at time of treatment with iNeST including one patient receiving combination therapy. We also observed a significant decrease in the cumulative recurrence rate post-treatment as compared to pre-treatment.

More about iNeST

mRNA
ITIT
BNT131
BNT131
PHASE
PRE123
Indication:
Solid Tumors
Rights/Collaborations:
Sanofi
PHASE
PRE123
Indication:
Solid Tumors
Rights/Collaborations:
Sanofi

Together with Sanofi we are developing SAR441000 (BNT131) as an intratumoral immunotherapy for the treatment of solid tumors. It utilizes mRNA to encode the cytokines IL-12sc, IL-15sushi, IFNα and…

Together with Sanofi we are developing SAR441000 (BNT131) as an intratumoral immunotherapy for the treatment of solid tumors. It utilizes mRNA to encode the cytokines IL-12sc, IL-15sushi, IFNα and GM-CSF. By increasing the concentration of these cytokines in the tumor microenvironment, the immune system may more easily recognize and fight cancer.

SAR441000 (BNT131) is being studied in a Phase 1 basket clinical trial as a monotherapy in patients with advanced melanoma and in combination with an anti-PD-1/PD-L1 checkpoint inhibitor in patients with advanced melanoma and certain solid tumors. Find out more about the study here.

DRUG CLASS

mRNA Therapeutics (mRNA)

We are utilizing messenger ribonucleic acid, or mRNA, to deliver genetic information to cells, where it is used to express proteins for therapeutic effect. We are developing a portfolio of immunotherapies that utilize four different mRNA formats and three different formulations to derive five distinct platforms for the treatment of cancer. Three of these platforms are currently in human testing:

  1. our off-the-shelf shared antigen immunotherapy, or FixVac
  2. our individualized neoantigen specific immunotherapy, or iNeST, in collaboration with Genentech
  3. our intratumoral immunotherapy, in collaboration with Sanofi.

In addition, we are developing two platforms in which we use mRNA to express directly in the patient either (a) particular antibodies, or RiboMabs, or (b) specific cytokines, or RiboCytokines. In collaboration with Pfizer and Genevant, we are also leveraging our mRNA technology beyond oncology to treat influenza and rare diseases.

More about mRNA

PLATFORM

Intratumoral Immunotherapies (ITIT)

Intratumoral Immunotherapies

  • Concept: Immunomodulator-encoding mRNA injected directly into the tumor in order to avoid off-target toxicities.
  • mRNA Format: Nucleoside-modified mRNA engineered for minimal immunogenicity in order to avoid immune detection and allow translation of the encoded cytokines to occur within the cells.
  • mRNA Delivery Formulation: Various formulations, delivered by intratumoral injection.
  • Development Approach: Co-development and co-commercialization, at our option, in collaboration with Sanofi.
  • Lead Candidate: SAR441000 (BNT131) for advanced solid tumors as a monotherapy and in combination with cemiplimab.

More about Intratumoral Immunotherapies

mRNA
rMAB
BNT141
BNT141
PHASE
PRE123
Indication:
Multiple Solid Tumors
Rights/Collaborations:
Global
PHASE
PRE123
Indication:
Multiple Solid Tumors
Rights/Collaborations:
Global

BNT141 is our RiboMab product candidate for the treatment of solid tumors currently in preclinical development. BNT141 is designed to encode secreted IgG antibodies that target multiple epithelial…

BNT141 is our RiboMab product candidate for the treatment of solid tumors currently in preclinical development. BNT141 is designed to encode secreted IgG antibodies that target multiple epithelial solid tumors, including gastric and pancreatic cancers.

DRUG CLASS

mRNA Therapeutics (mRNA)

We are utilizing messenger ribonucleic acid, or mRNA, to deliver genetic information to cells, where it is used to express proteins for therapeutic effect. We are developing a portfolio of immunotherapies that utilize four different mRNA formats and three different formulations to derive five distinct platforms for the treatment of cancer. Three of these platforms are currently in human testing:

  1. our off-the-shelf shared antigen immunotherapy, or FixVac
  2. our individualized neoantigen specific immunotherapy, or iNeST, in collaboration with Genentech
  3. our intratumoral immunotherapy, in collaboration with Sanofi.

In addition, we are developing two platforms in which we use mRNA to express directly in the patient either (a) particular antibodies, or RiboMabs, or (b) specific cytokines, or RiboCytokines. In collaboration with Pfizer and Genevant, we are also leveraging our mRNA technology beyond oncology to treat influenza and rare diseases.

More about mRNA

PLATFORM

RiboMabs (rMAB)

RiboMabs

  • Concept: Antibodies encoded by mRNA and produced in the patient as an alternative to recombinant antibodies.
  • mRNA Format: Nucleoside-modified mRNA engineered for minimal immunogenicity in order to avoid immune detection and allow translation of the encoded antibodies to occur within the cells.
  • mRNA Delivery Formulation: Various liver-targeting LNP formulations, delivered intravenously, to ensure systemic availability and prolonged production of the antibody in vivo.
  • Development Approach: Worldwide rights; wholly owned.
  • Lead Candidate: BNT141 in multiple solid tumors.

More about RiboMabs

mRNA
rMAB
BNT142
BNT142
PHASE
PRE123
Indication:
Multiple Solid Tumors
Rights/Collaborations:
Global
PHASE
PRE123
Indication:
Multiple Solid Tumors
Rights/Collaborations:
Global

BNT142 is designed to encode a secreted bispecific antibody that targets CD3 and CLDN6. It is currently in preclinical development for the treatment of solid tumors.

BNT142 is designed to encode a secreted bispecific antibody that targets CD3 and CLDN6. It is currently in preclinical development for the treatment of solid tumors.

DRUG CLASS

mRNA Therapeutics (mRNA)

We are utilizing messenger ribonucleic acid, or mRNA, to deliver genetic information to cells, where it is used to express proteins for therapeutic effect. We are developing a portfolio of immunotherapies that utilize four different mRNA formats and three different formulations to derive five distinct platforms for the treatment of cancer. Three of these platforms are currently in human testing:

  1. our off-the-shelf shared antigen immunotherapy, or FixVac
  2. our individualized neoantigen specific immunotherapy, or iNeST, in collaboration with Genentech
  3. our intratumoral immunotherapy, in collaboration with Sanofi.

In addition, we are developing two platforms in which we use mRNA to express directly in the patient either (a) particular antibodies, or RiboMabs, or (b) specific cytokines, or RiboCytokines. In collaboration with Pfizer and Genevant, we are also leveraging our mRNA technology beyond oncology to treat influenza and rare diseases.

More about mRNA

PLATFORM

RiboMabs (rMAB)

RiboMabs

  • Concept: Antibodies encoded by mRNA and produced in the patient as an alternative to recombinant antibodies.
  • mRNA Format: Nucleoside-modified mRNA engineered for minimal immunogenicity in order to avoid immune detection and allow translation of the encoded antibodies to occur within the cells.
  • mRNA Delivery Formulation: Various liver-targeting LNP formulations, delivered intravenously, to ensure systemic availability and prolonged production of the antibody in vivo.
  • Development Approach: Worldwide rights; wholly owned.
  • Lead Candidate: BNT141 in multiple solid tumors.

More about RiboMabs

mRNA
rCK
BNT151
BNT151
PHASE
PRE123
Indication:
Multiple Solid Tumors
Rights/Collaborations:
Global
PHASE
PRE123
Indication:
Multiple Solid Tumors
Rights/Collaborations:
Global

BNT151 encodes a modified version of the human interleukin-2, or IL-2, cytokine. It is in preclinical development for the treatment of solid tumors. BNT151 is designed to stimulate T cells without…

BNT151 encodes a modified version of the human interleukin-2, or IL-2, cytokine. It is in preclinical development for the treatment of solid tumors. BNT151 is designed to stimulate T cells without triggering immunosuppression in the tumor microenvironment.

DRUG CLASS

mRNA Therapeutics (mRNA)

We are utilizing messenger ribonucleic acid, or mRNA, to deliver genetic information to cells, where it is used to express proteins for therapeutic effect. We are developing a portfolio of immunotherapies that utilize four different mRNA formats and three different formulations to derive five distinct platforms for the treatment of cancer. Three of these platforms are currently in human testing:

  1. our off-the-shelf shared antigen immunotherapy, or FixVac
  2. our individualized neoantigen specific immunotherapy, or iNeST, in collaboration with Genentech
  3. our intratumoral immunotherapy, in collaboration with Sanofi.

In addition, we are developing two platforms in which we use mRNA to express directly in the patient either (a) particular antibodies, or RiboMabs, or (b) specific cytokines, or RiboCytokines. In collaboration with Pfizer and Genevant, we are also leveraging our mRNA technology beyond oncology to treat influenza and rare diseases.

More about mRNA

PLATFORM

RiboCytokines (rCK)

RiboCytokines

  • Concept: Cytokines encoded by mRNA and produced in the patient as an alternative to recombinant cytokines.
  • mRNA Format: Nucleoside-modified mRNA engineered for minimal immunogenicity in order to avoid immune detection and allow translation of the encoded cytokines to occur within the cells.
  • mRNA Delivery Formulation: Various liver-targeting LNP formulations, delivered intravenously, to ensure systemic availability and prolonged production of the cytokine in vivo.
  • Development Approach: Worldwide rights; wholly owned.
  • Lead Candidate: BNT151 in multiple advanced malignancies.

More about RiboCytokines

mRNA
rCK
BNT152, BNT153
BNT152, BNT153
PHASE
PRE123
Indication:
Multiple Solid Tumors
Rights/Collaborations:
Global
PHASE
PRE123
Indication:
Multiple Solid Tumors
Rights/Collaborations:
Global

BNT152 and BNT153 are RiboCytokines designed to encode IL-7 and IL-2 for the treatment of solid tumors. The program is currently in preclinical development.

BNT152 and BNT153 are RiboCytokines designed to encode IL-7 and IL-2 for the treatment of solid tumors. The program is currently in preclinical development.

DRUG CLASS

mRNA Therapeutics (mRNA)

We are utilizing messenger ribonucleic acid, or mRNA, to deliver genetic information to cells, where it is used to express proteins for therapeutic effect. We are developing a portfolio of immunotherapies that utilize four different mRNA formats and three different formulations to derive five distinct platforms for the treatment of cancer. Three of these platforms are currently in human testing:

  1. our off-the-shelf shared antigen immunotherapy, or FixVac
  2. our individualized neoantigen specific immunotherapy, or iNeST, in collaboration with Genentech
  3. our intratumoral immunotherapy, in collaboration with Sanofi.

In addition, we are developing two platforms in which we use mRNA to express directly in the patient either (a) particular antibodies, or RiboMabs, or (b) specific cytokines, or RiboCytokines. In collaboration with Pfizer and Genevant, we are also leveraging our mRNA technology beyond oncology to treat influenza and rare diseases.

More about mRNA

PLATFORM

RiboCytokines (rCK)

RiboCytokines

  • Concept: Cytokines encoded by mRNA and produced in the patient as an alternative to recombinant cytokines.
  • mRNA Format: Nucleoside-modified mRNA engineered for minimal immunogenicity in order to avoid immune detection and allow translation of the encoded cytokines to occur within the cells.
  • mRNA Delivery Formulation: Various liver-targeting LNP formulations, delivered intravenously, to ensure systemic availability and prolonged production of the cytokine in vivo.
  • Development Approach: Worldwide rights; wholly owned.
  • Lead Candidate: BNT151 in multiple advanced malignancies.

More about RiboCytokines

mRNA
INF
BNT161
BNT161
PHASE
PRE123
Indication:
Influenza
Rights/Collaborations:
Pfizer
PHASE
PRE123
Indication:
Influenza
Rights/Collaborations:
Pfizer

We are collaborating with Pfizer to develop an influenza vaccine based on our mRNA drug classes. Our product candidate BNT161 will encode influenza virus antigens selected by the WHO in advance of…

We are collaborating with Pfizer to develop an influenza vaccine based on our mRNA drug classes. Our product candidate BNT161 will encode influenza virus antigens selected by the WHO in advance of the flu season.

DRUG CLASS

mRNA Therapeutics (mRNA)

We are utilizing messenger ribonucleic acid, or mRNA, to deliver genetic information to cells, where it is used to express proteins for therapeutic effect. We are developing a portfolio of immunotherapies that utilize four different mRNA formats and three different formulations to derive five distinct platforms for the treatment of cancer. Three of these platforms are currently in human testing:

  1. our off-the-shelf shared antigen immunotherapy, or FixVac
  2. our individualized neoantigen specific immunotherapy, or iNeST, in collaboration with Genentech
  3. our intratumoral immunotherapy, in collaboration with Sanofi.

In addition, we are developing two platforms in which we use mRNA to express directly in the patient either (a) particular antibodies, or RiboMabs, or (b) specific cytokines, or RiboCytokines. In collaboration with Pfizer and Genevant, we are also leveraging our mRNA technology beyond oncology to treat influenza and rare diseases.

More about mRNA

PLATFORM

Infectious Disease Immunotherapies (INF)

Infectious Disease Immunotherapies

  • Concept: mRNA-based vaccines targeting infectious disease pathogens.
  • mRNA Format: Self-amplifying mRNA providing high immunogenicity with smaller amounts of mRNA.
  • mRNA Delivery Formulation: Lipid nanoparticles (LNPs).
  • Development Approach: Collaboration with Pfizer and exclusive option arrangement with Penn.
  • Lead Candidate: Influenza vaccine.

More about Infectious Disease Immunotherapies

mRNA
INF 2
BNT162
BNT162
PHASE
PRE123
Indication:
COVID-19
Rights/Collaborations:
Fosun Pharma (China), BioNTech (Global, except China)
PHASE
PRE123
Indication:
COVID-19
Rights/Collaborations:
Fosun Pharma (China), BioNTech (Global, except China)

BNT162 is BioNTech’s mRNA vaccine program aimed at preventing COVID-19 infection. It is the first product candidate from Project Lightspeed and leverages BioNTech’s proprietary mRNA platforms for…

BNT162 is BioNTech’s mRNA vaccine program aimed at preventing COVID-19 infection. It is the first product candidate from Project Lightspeed and leverages BioNTech’s proprietary mRNA platforms for infectious diseases, its fully-owned GMP manufacturing infrastructure for mRNA vaccine production, and its global clinical development capabilities, drawing on BioNTech’s broad network of global collaborators.

DRUG CLASS

mRNA Therapeutics (mRNA)

We are utilizing messenger ribonucleic acid, or mRNA, to deliver genetic information to cells, where it is used to express proteins for therapeutic effect. We are developing a portfolio of immunotherapies that utilize four different mRNA formats and three different formulations to derive five distinct platforms for the treatment of cancer. Three of these platforms are currently in human testing:

  1. our off-the-shelf shared antigen immunotherapy, or FixVac
  2. our individualized neoantigen specific immunotherapy, or iNeST, in collaboration with Genentech
  3. our intratumoral immunotherapy, in collaboration with Sanofi.

In addition, we are developing two platforms in which we use mRNA to express directly in the patient either (a) particular antibodies, or RiboMabs, or (b) specific cytokines, or RiboCytokines. In collaboration with Pfizer and Genevant, we are also leveraging our mRNA technology beyond oncology to treat influenza and rare diseases.

More about mRNA

PLATFORM

Infectious Disease Immunotherapies (INF 2)

Infectious Disease Immunotherapies

  • Concept: mRNA-based vaccine targeting infectious disease pathogens.
  • mRNA Formats: uridine-containing mRNA (uRNA), nucleoside modified mRNA (modRNA), and self-amplifying mRNA (saRNA) providing high immunogenicity.
  • mRNA Delivery Formulation: Lipid nanoparticles (LNPs).
  • Development Approach: Global development program, in collaboration with Fosun Pharma.
  • Lead Candidate: COVID-19 Vaccine.

More about Infectious Disease Immunotherapies

mRNA
RD
BNT171
BNT171
PHASE
PRE123
Indication:
Not disclosed
Rights/Collaborations:
Genevant
PHASE
PRE123
Indication:
Not disclosed
Rights/Collaborations:
Genevant

Target not selected

Target not selected

DRUG CLASS

mRNA Therapeutics (mRNA)

We are utilizing messenger ribonucleic acid, or mRNA, to deliver genetic information to cells, where it is used to express proteins for therapeutic effect. We are developing a portfolio of immunotherapies that utilize four different mRNA formats and three different formulations to derive five distinct platforms for the treatment of cancer. Three of these platforms are currently in human testing:

  1. our off-the-shelf shared antigen immunotherapy, or FixVac
  2. our individualized neoantigen specific immunotherapy, or iNeST, in collaboration with Genentech
  3. our intratumoral immunotherapy, in collaboration with Sanofi.

In addition, we are developing two platforms in which we use mRNA to express directly in the patient either (a) particular antibodies, or RiboMabs, or (b) specific cytokines, or RiboCytokines. In collaboration with Pfizer and Genevant, we are also leveraging our mRNA technology beyond oncology to treat influenza and rare diseases.

More about mRNA

PLATFORM

Rare Disease PRT (RD)

Rare Disease PRT

  • Concept: Therapeutic proteins encoded by mRNA and produced in the patient as an alternative to recombinant protein replacement.
  • mRNA Format: Nucleoside-modified mRNA, deimmunized to avoid immune activation in order to allow for translation of the therapeutic protein in the cells.
  • mRNA Delivery Formulation: Liver-targeting LNPs.
  • Development Approach: 50:50 cost and profit share with Genevant.

More about Rare Disease PRT

ECT
CAR T
BNT211
BNT211
PHASE
PRE123
Indication:
Multiple Solid Tumors
Rights/Collaborations:
Global
PHASE
PRE123
Indication:
Multiple Solid Tumors
Rights/Collaborations:
Global

BNT211 is our CAR T cell therapy for the treatment of CLDN6-positive solid tumors. BNT211 targets CLDN6 and will initially be evaluated in combination with a FixVac that encodes CLDN6.

…

BNT211 is our CAR T cell therapy for the treatment of CLDN6-positive solid tumors. BNT211 targets CLDN6 and will initially be evaluated in combination with a FixVac that encodes CLDN6.

CLDN6 is a highly specific oncofetal cell surface antigen that is found in multiple cancers, including ovarian, testicular and lung cancers, but not in normal cells. We have observed compelling preclinical data, demonstrating potent anti-tumoral efficacy, including eradication of advanced tumors in an ovarian carcinoma xenograft model.

DRUG CLASS

Engineered Cell Therapies (ECT)

We are developing a range of novel cell therapies in which the patient’s T cells are modified to target cancer-specific antigens. These include two platforms for the treatment of solid tumors: chimeric antigen receptor, or CAR, T cells and T cell receptor, or TCR, programs. We are also combining our mRNA FixVac platform with our first CAR T product candidates to enhance the persistence of CAR-T cells in vivo.

More about Engineered Cell Therapies

PLATFORM

CAR T Cell Platform (CAR T)

CAR T Cell Platform

  • Concept: Second-generation CAR T therapy designed to overcome the shortcomings of CAR T therapy in solid tumors.
  • Mechanism: T cells with CARs engineered to target cancer-specific antigens, including novel antigens selected from our proprietary antigen library and administered with a FixVac immune booster to enhance CAR-T cell expansion and persistence.
  • Development Approach: Worldwide rights; wholly owned.
  • Lead Candidate: BNT211 for multiple solid tumors.

More about the CAR T Cell Platform

ECT
CAR T
BNT212
BNT212
PHASE
PRE123
Indication:
Pancreatic, Other Cancers
Rights/Collaborations:
Global
PHASE
PRE123
Indication:
Pancreatic, Other Cancers
Rights/Collaborations:
Global

BNT212 is under development for the treatment of CLDN18.2-positive solid tumors and will initially be evaluated in combination with a FixVac that encodes CLDN18.2. BNT212 targets Claudin 18.2, or…

BNT212 is under development for the treatment of CLDN18.2-positive solid tumors and will initially be evaluated in combination with a FixVac that encodes CLDN18.2. BNT212 targets Claudin 18.2, or CLDN18.2. CLDN18.2 is a highly specific target which is only expressed in cancer and in differentiated epithelial cells of the gastric mucosa, but it is absent from the gastric stem cell zone. CLDN18.2 is expressed in numerous epithelial solid tumors, including gastric, pancreatic, esophageal, ovarian and lung tumors.

DRUG CLASS

Engineered Cell Therapies (ECT)

We are developing a range of novel cell therapies in which the patient’s T cells are modified to target cancer-specific antigens. These include two platforms for the treatment of solid tumors: chimeric antigen receptor, or CAR, T cells and T cell receptor, or TCR, programs. We are also combining our mRNA FixVac platform with our first CAR T product candidates to enhance the persistence of CAR-T cells in vivo.

More about Engineered Cell Therapies

PLATFORM

CAR T Cell Platform (CAR T)

CAR T Cell Platform

  • Concept: Second-generation CAR T therapy designed to overcome the shortcomings of CAR T therapy in solid tumors.
  • Mechanism: T cells with CARs engineered to target cancer-specific antigens, including novel antigens selected from our proprietary antigen library and administered with a FixVac immune booster to enhance CAR-T cell expansion and persistence.
  • Development Approach: Worldwide rights; wholly owned.
  • Lead Candidate: BNT211 for multiple solid tumors.

More about the CAR T Cell Platform

AB
NGIM
BNT311
BNT311
PHASE
PRE123
Indication:
Multiple Solid Tumors
Rights/Collaborations:
Genmab
PHASE
PRE123
Indication:
Multiple Solid Tumors
Rights/Collaborations:
Genmab

GEN1046 (BNT311) is a bispecific antibody designed to target PD-L1 and 4-1BB to block the inhibitory PD-1/PD-L1 axis and simultaneously activate essential co-stimulatory activity via 4-1BB.

…

GEN1046 (BNT311) is a bispecific antibody designed to target PD-L1 and 4-1BB to block the inhibitory PD-1/PD-L1 axis and simultaneously activate essential co-stimulatory activity via 4-1BB.

PD-L1 is a validated target that is expressed on tumor cells. 4-1BB is a trans-membrane receptor belonging to the TNF super-family and is expressed predominantly on activated T cells.

In collaboration with Genmab, we are conducting a Phase 1/2, open-label, single arm safety basket trial of GEN1046 (BNT311). Find out more about the study here. We have announced the dosing of the first patient in June 2019. See the press release here.

DRUG CLASS

Antibodies (AB)

We are developing, in collaboration with Genmab, next-generation bispecific antibodies that are designed to target immune checkpoints that modulate the patient’s immune response to cancer. We are also exploring additional targeted cancer antibody approaches utilizing our in-house and recently acquired antibody capabilities.

More about Antibodies

PLATFORM

Next-Gen Checkpoint Immunomodulators (NGIM)

Next-Gen Checkpoint Immunomodulators

  • Concept: Bispecific antibodies for dual immunomodulation, initially targeting 4-1BB, an immune checkpoint that is expressed on T cells and NK cells and can enhance immune cell proliferation and activation, in combination with simultaneous checkpoint inhibition.
  • Mechanism: Conditional activation of 4-1BB checkpoint only upon simultaneous binding of PD-L1 or CD40 (in the case of our initial candidates), potentially avoiding toxicities seen in prior attempts at 4-1BB agonism by localizing 4-1BB activation to the tumor environment.
  • Development Approach: 50:50 cost and profit share with Genmab, combining our and Genmab’s immunostimulatory antibodies and extensive immunology expertise with Genmab’s DuoBody bispecific antibody platform.
  • Lead Candidate: GEN1046 (BNT311), our PD-L1x4-1BB product candidate for multiple solid tumors.

More about Next-Gen Checkpoint Immunomodulators

AB
NGIM
BNT312
BNT312
PHASE
PRE123
Indication:
Multiple Solid Tumors
Rights/Collaborations:
Genmab
PHASE
PRE123
Indication:
Multiple Solid Tumors
Rights/Collaborations:
Genmab

GEN1042 (BNT312) is a bispecific antibody designed to activate an anti-tumor immune response through conditional CD40-mediated stimulation of antigen presenting cells crosslinked with conditional…

GEN1042 (BNT312) is a bispecific antibody designed to activate an anti-tumor immune response through conditional CD40-mediated stimulation of antigen presenting cells crosslinked with conditional stimulation of 4-1BB-positive T cells. The cell surface molecule CD40 is a member of the tumor necrosis factor receptor superfamily and is broadly expressed by a wide range of tumor cells. The candidate has completed preclinical development and entered clinical development in 2019. Find out more about the study here.

DRUG CLASS

Antibodies (AB)

We are developing, in collaboration with Genmab, next-generation bispecific antibodies that are designed to target immune checkpoints that modulate the patient’s immune response to cancer. We are also exploring additional targeted cancer antibody approaches utilizing our in-house and recently acquired antibody capabilities.

More about Antibodies

PLATFORM

Next-Gen Checkpoint Immunomodulators (NGIM)

Next-Gen Checkpoint Immunomodulators

  • Concept: Bispecific antibodies for dual immunomodulation, initially targeting 4-1BB, an immune checkpoint that is expressed on T cells and NK cells and can enhance immune cell proliferation and activation, in combination with simultaneous checkpoint inhibition.
  • Mechanism: Conditional activation of 4-1BB checkpoint only upon simultaneous binding of PD-L1 or CD40 (in the case of our initial candidates), potentially avoiding toxicities seen in prior attempts at 4-1BB agonism by localizing 4-1BB activation to the tumor environment.
  • Development Approach: 50:50 cost and profit share with Genmab, combining our and Genmab’s immunostimulatory antibodies and extensive immunology expertise with Genmab’s DuoBody bispecific antibody platform.
  • Lead Candidate: GEN1046 (BNT311), our PD-L1x4-1BB product candidate for multiple solid tumors.

More about Next-Gen Checkpoint Immunomodulators

AB
tCaAb
BNT321
BNT321
PHASE
PRE123
Indication:
Pancreatic Cancer
Rights/Collaborations:
Global
PHASE
PRE123
Indication:
Pancreatic Cancer
Rights/Collaborations:
Global

MVT-5873 (BNT321) is a fully human IgG1 monoclonal antibody targeting sialyl Lewis A (sLea), an epitope on CA19-9 that is expressed in pancreatic and other gastrointestinal cancers that plays a…

MVT-5873 (BNT321) is a fully human IgG1 monoclonal antibody targeting sialyl Lewis A (sLea), an epitope on CA19-9 that is expressed in pancreatic and other gastrointestinal cancers that plays a role in tumor adhesion and metastasis formation, and is a marker of an aggressive cancer phenotype.

MVT-5873 (BNT321) is being investigated in an open-label, multi-center, non-randomized dose escalation Phase 1/2 study evaluating the safety and recommended Phase 2 dose of MVT-5873 (BNT321) both as a monotherapy and in combination with a standard of care chemotherapy. Find out more about the study here.

DRUG CLASS

Antibodies (AB)

We are developing, in collaboration with Genmab, next-generation bispecific antibodies that are designed to target immune checkpoints that modulate the patient’s immune response to cancer. We are also exploring additional targeted cancer antibody approaches utilizing our in-house and recently acquired antibody capabilities.

More about Antibodies

PLATFORM

Targeted Cancer Antibodies (tCaAb)

Targeted Cancer Antibodies

Our multiple antibody discovery engines significantly expand our targeting repertoire and enable us to directly, rapidly and efficiently produce new mAb candidates. With the acquisition of MAB Discovery GmbH’s antibody generation unit in 2019, we integrated a unique and proprietary rabbit-based antibody discovery platform that can generate and develop high quality, functional mAbs targeting traditional proteins and receptors as well as a wide variety of more challenging targets. HuMab, our human antibody discovery engine acquired from MabVax Therapeutics in 2019, led to the clinical development of our fully human IgG1 monoclonal antibody product candidate targeting Sialyl Lewisa (sLea), a carbohydrate moiety that is present in over 90% of pancreatic and a large percentage of gastrointestinal cancers.

SMIM
TLR
BNT411
BNT411
PHASE
PRE123
Indication:
Solid Tumors
Rights/Collaborations:
Global
PHASE
PRE123
Indication:
Solid Tumors
Rights/Collaborations:
Global

BNT411 is a TLR7 agonist that is designed to activate both the adaptive and innate immune system through the TLR7 pathway. This activity and the release of cytokines and chemokines are designed to…

BNT411 is a TLR7 agonist that is designed to activate both the adaptive and innate immune system through the TLR7 pathway. This activity and the release of cytokines and chemokines are designed to result in the potent stimulation of antigen specific CD8+ T cells, B cells and innate immune cells such as NK cells and macrophages.

BNT411 is currently in preclinical development and is designed to be used in combination with chemotherapy and checkpoint inhibitors.

DRUG CLASS

Small Molecule Immunomodulators (SMIM)

We use small molecules to augment the activity of other drug classes by inducing specific and discrete patterns of immunomodulation. We are developing a small molecule toll-like receptor 7, or TLR7, immunomodulator for the treatment of solid tumors.

More about Small Molecule Immunomodulators

PLATFORM

Toll-Like Receptor Binding (TLR)

Toll-Like Receptor Binding

  • Concept: Small molecule therapies, with a specific focus on TLRs, that can be used synergistically with other cancer therapeutics, including other product candidates in our portfolio.
  • Development Approach: Worldwide rights; wholly owned.
  • Lead Candidate: BNT411, our TLR7 agonist product candidate intended for combination therapies.

More about Toll-Like Receptor Bindings

ECT
TCR
To be selected
To be selected
PHASE
PRE123
Indication:
All Tumors
Rights/Collaborations:
Global
PHASE
PRE123
Indication:
All Tumors
Rights/Collaborations:
Global

Target not selected

Target not selected

DRUG CLASS

Engineered Cell Therapies (ECT)

We are developing a range of novel cell therapies in which the patient’s T cells are modified to target cancer-specific antigens. These include two platforms for the treatment of solid tumors: chimeric antigen receptor, or CAR, T cells and T cell receptor, or TCR, programs. We are also combining our mRNA FixVac platform with our first CAR T product candidates to enhance the persistence of CAR-T cells in vivo.

More about Engineered Cell Therapies

PLATFORM

T Cell Receptor Cell Platform (TCR)

T Cell Receptor Cell Platform

We are developing T cell receptor therapies for the treatment of cancer, including in collaboration with Eli Lilly. Under our collaboration, Eli Lilly has an exclusive option to pursue clinical development of certain potential TCR product candidates. We and Eli Lilly have concluded the research phase of the collaboration and Eli Lilly is evaluating whether to exercise its option.

More about the T Cell Receptor Cell Platform

mRNA
INF
To be selected
To be selected
PHASE
PRE123
Indication:
Up to 10 Indications
Rights/Collaborations:
Penn
PHASE
PRE123
Indication:
Up to 10 Indications
Rights/Collaborations:
Penn

Target not selected

Target not selected

DRUG CLASS

mRNA Therapeutics (mRNA)

We are utilizing messenger ribonucleic acid, or mRNA, to deliver genetic information to cells, where it is used to express proteins for therapeutic effect. We are developing a portfolio of immunotherapies that utilize four different mRNA formats and three different formulations to derive five distinct platforms for the treatment of cancer. Three of these platforms are currently in human testing:

  1. our off-the-shelf shared antigen immunotherapy, or FixVac
  2. our individualized neoantigen specific immunotherapy, or iNeST, in collaboration with Genentech
  3. our intratumoral immunotherapy, in collaboration with Sanofi.

In addition, we are developing two platforms in which we use mRNA to express directly in the patient either (a) particular antibodies, or RiboMabs, or (b) specific cytokines, or RiboCytokines. In collaboration with Pfizer and Genevant, we are also leveraging our mRNA technology beyond oncology to treat influenza and rare diseases.

More about mRNA

PLATFORM

Infectious Disease Immunotherapies (INF)

Infectious Disease Immunotherapies

  • Concept: mRNA-based vaccines targeting infectious disease pathogens.
  • mRNA Format: Self-amplifying mRNA providing high immunogenicity with smaller amounts of mRNA.
  • mRNA Delivery Formulation: Lipid nanoparticles (LNPs).
  • Development Approach: Collaboration with Pfizer and exclusive option arrangement with Penn.
  • Lead Candidate: Influenza vaccine.

More about Infectious Disease Immunotherapies

mRNA
INF
To be selected
To be selected
PHASE
PRE123
Indication:
HIV
Rights/Collaborations:
Bill and Melinda Gates Foundation
PHASE
PRE123
Indication:
HIV
Rights/Collaborations:
Bill and Melinda Gates Foundation

Target not selected

Target not selected

DRUG CLASS

mRNA Therapeutics (mRNA)

We are utilizing messenger ribonucleic acid, or mRNA, to deliver genetic information to cells, where it is used to express proteins for therapeutic effect. We are developing a portfolio of immunotherapies that utilize four different mRNA formats and three different formulations to derive five distinct platforms for the treatment of cancer. Three of these platforms are currently in human testing:

  1. our off-the-shelf shared antigen immunotherapy, or FixVac
  2. our individualized neoantigen specific immunotherapy, or iNeST, in collaboration with Genentech
  3. our intratumoral immunotherapy, in collaboration with Sanofi.

In addition, we are developing two platforms in which we use mRNA to express directly in the patient either (a) particular antibodies, or RiboMabs, or (b) specific cytokines, or RiboCytokines. In collaboration with Pfizer and Genevant, we are also leveraging our mRNA technology beyond oncology to treat influenza and rare diseases.

More about mRNA

PLATFORM

Infectious Disease Immunotherapies (INF)

Infectious Disease Immunotherapies

  • Concept: mRNA-based vaccines targeting infectious disease pathogens.
  • mRNA Format: Self-amplifying mRNA providing high immunogenicity with smaller amounts of mRNA.
  • mRNA Delivery Formulation: Lipid nanoparticles (LNPs).
  • Development Approach: Collaboration with Pfizer and exclusive option arrangement with Penn.
  • Lead Candidate: Influenza vaccine.

More about Infectious Disease Immunotherapies

mRNA
INF
To be selected
To be selected
PHASE
PRE123
Indication:
Tuberculosis
Rights/Collaborations:
Bill and Melinda Gates Foundation
PHASE
PRE123
Indication:
Tuberculosis
Rights/Collaborations:
Bill and Melinda Gates Foundation

Target not selected

Target not selected

DRUG CLASS

mRNA Therapeutics (mRNA)

We are utilizing messenger ribonucleic acid, or mRNA, to deliver genetic information to cells, where it is used to express proteins for therapeutic effect. We are developing a portfolio of immunotherapies that utilize four different mRNA formats and three different formulations to derive five distinct platforms for the treatment of cancer. Three of these platforms are currently in human testing:

  1. our off-the-shelf shared antigen immunotherapy, or FixVac
  2. our individualized neoantigen specific immunotherapy, or iNeST, in collaboration with Genentech
  3. our intratumoral immunotherapy, in collaboration with Sanofi.

In addition, we are developing two platforms in which we use mRNA to express directly in the patient either (a) particular antibodies, or RiboMabs, or (b) specific cytokines, or RiboCytokines. In collaboration with Pfizer and Genevant, we are also leveraging our mRNA technology beyond oncology to treat influenza and rare diseases.

More about mRNA

PLATFORM

Infectious Disease Immunotherapies (INF)

Infectious Disease Immunotherapies

  • Concept: mRNA-based vaccines targeting infectious disease pathogens.
  • mRNA Format: Self-amplifying mRNA providing high immunogenicity with smaller amounts of mRNA.
  • mRNA Delivery Formulation: Lipid nanoparticles (LNPs).
  • Development Approach: Collaboration with Pfizer and exclusive option arrangement with Penn.
  • Lead Candidate: Influenza vaccine.

More about Infectious Disease Immunotherapies

mRNA
RD
To be selected
To be selected
PHASE
PRE123
Indication:
4 More Rare Disease Indications
Rights/Collaborations:
Genevant
PHASE
PRE123
Indication:
4 More Rare Disease Indications
Rights/Collaborations:
Genevant

Target not selected

Target not selected

DRUG CLASS

mRNA Therapeutics (mRNA)

We are utilizing messenger ribonucleic acid, or mRNA, to deliver genetic information to cells, where it is used to express proteins for therapeutic effect. We are developing a portfolio of immunotherapies that utilize four different mRNA formats and three different formulations to derive five distinct platforms for the treatment of cancer. Three of these platforms are currently in human testing:

  1. our off-the-shelf shared antigen immunotherapy, or FixVac
  2. our individualized neoantigen specific immunotherapy, or iNeST, in collaboration with Genentech
  3. our intratumoral immunotherapy, in collaboration with Sanofi.

In addition, we are developing two platforms in which we use mRNA to express directly in the patient either (a) particular antibodies, or RiboMabs, or (b) specific cytokines, or RiboCytokines. In collaboration with Pfizer and Genevant, we are also leveraging our mRNA technology beyond oncology to treat influenza and rare diseases.

More about mRNA

PLATFORM

Rare Disease PRT (RD)

Rare Disease PRT

  • Concept: Therapeutic proteins encoded by mRNA and produced in the patient as an alternative to recombinant protein replacement.
  • mRNA Format: Nucleoside-modified mRNA, deimmunized to avoid immune activation in order to allow for translation of the therapeutic protein in the cells.
  • mRNA Delivery Formulation: Liver-targeting LNPs.
  • Development Approach: 50:50 cost and profit share with Genevant.

More about Rare Disease PRT

ECT
TCR
Undisclosed
Undisclosed
PHASE
PRE123
Indication:
Solid Tumors
Rights/Collaborations:
Eli Lilly
PHASE
PRE123
Indication:
Solid Tumors
Rights/Collaborations:
Eli Lilly

Target undisclosed

Target undisclosed

DRUG CLASS

Engineered Cell Therapies (ECT)

We are developing a range of novel cell therapies in which the patient’s T cells are modified to target cancer-specific antigens. These include two platforms for the treatment of solid tumors: chimeric antigen receptor, or CAR, T cells and T cell receptor, or TCR, programs. We are also combining our mRNA FixVac platform with our first CAR T product candidates to enhance the persistence of CAR-T cells in vivo.

More about Engineered Cell Therapies

PLATFORM

T Cell Receptor Cell Platform (TCR)

T Cell Receptor Cell Platform

We are developing T cell receptor therapies for the treatment of cancer, including in collaboration with Eli Lilly. Under our collaboration, Eli Lilly has an exclusive option to pursue clinical development of certain potential TCR product candidates. We and Eli Lilly have concluded the research phase of the collaboration and Eli Lilly is evaluating whether to exercise its option.

More about the T Cell Receptor Cell Platform

DRUGCLASS
PLATFORM
PHASE
PARTNERS

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